More than 200,000 men worldwide are affected by erectile dysfunction. Viagra (sildenafil) is a vasodilator that can treat erectile dysfunction. It can also treat hypertension, also known as high blood pressure. It works by increasing blood flow to the penis in order to help a man get and sustain an erection when he is sexually aroused or stimulated. Sildenafil protects cyclic guanosine monophosphate (cGMP) from degradation by cGMP-specific phosphodiesterase type 5 (PDE5) in the corpus cavernosum. Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation (vasodilation) of the intimal cushions of the helicine arteries. This smooth muscle relaxation leads to vasodilation and increased inflow of blood into the spongy tissue of the penis, causing an erection. Robert F. Furchgott, Ferid Murad, and Louis Ignarro won the Nobel Prize in Physiology or Medicine in 1998 for their independent study of the metabolic pathway of nitric oxide in smooth muscle vasodilation.
Viagra in Australia
How its working?
Sildenafil is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), which is responsible for degradation of cGMP in the corpus cavernosum. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections. Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, sildenafil should not cause an erection. Other drugs that operate by the same mechanism include tadalafil (Cialis) and vardenafil (Levitra). Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4(major route), but also by CYP2C9 (minor route) hepatic isoenzymes. The major product of metabolization by these enzymes is N-demethylated sildenafil, which is metabolised further. This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil. Thus, the metabolite is responsible for about 20% of sildenafil action. Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose). If taken with a high-fat meal, absorption is reduced; the time taken to reach the maximum plasma concentration increases by around one hour, and the maximum concentration itself is decreased by nearly one-third.
It only works when the man is sexually stimulated. This drug cannot be used by women. Women should not be taking Viagra. Serious interactions can occur if taken with alcohol so make sure to avoid that. Do not take it if you take any medicines called nitrates, often prescribed for chest pain, or guanylate cyclase stimulators like Adempas for pulmonary hypertension. Your blood pressure could drop to an unsafe level. Some side effects are loss of vision, sudden hearing loss, and erections that won’t go away. It is by far the most common drug used for erectile dysfunction. It has an excellent safety record.
Buy Viagra in Australia
You can buy it in many forms in Australia using the website https://www.edonlinestores.net. They have a form that comes with Priligy, which is the first premature ejaculation treatment. So you can have both medications combined into one pill if you suffer from both issues. This website has over 30,000 customers. They have discreet shipping, the cheapest prices in Australia, and traceable delivery. Viagra’s effects usually last somewhere between 5-6 hours, and it starts working within an hour. You can take up to one a day if you’d like. exceeding beyond that might be hazardous to health and is not recommended. The price per pill is somewhere in the margin of 2-3 AU. That is a relatively good price.